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Are multiple primary outcomes analysed appropriately in randomised controlled trials? A review

Vickerstaff, V; Ambler, G; King, M; Nazareth, I; Omar, RZ; (2015) Are multiple primary outcomes analysed appropriately in randomised controlled trials? A review. Contemporary Clinical Trials , 45 (A) pp. 8-12. 10.1016/j.cct.2015.07.016. Green open access

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Abstract

To review how multiple primary outcomes are currently considered in the analysis of randomised controlled trials. We briefly describe the methods available to safeguard the inferences and to raise awareness of the potential problems caused by multiple outcomes.

Type: Article
Title: Are multiple primary outcomes analysed appropriately in randomised controlled trials? A review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cct.2015.07.016
Publisher version: http://dx.doi.org/10.1016/j.cct.2015.07.016
Language: English
Additional information: © 2015 Elsevier B.V. This manuscript is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Clinical trials, Multiple outcomes, Multiplicity, Neurology, Psychiatry
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science
URI: https://discovery.ucl.ac.uk/id/eprint/1470150
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