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Orofacial Granulomatosis

Al-Hamad, A; Porter, S; Fedele, S; (2015) Orofacial Granulomatosis. Dermatologic Clinics , 33 (3) pp. 433-446. 10.1016/j.det.2015.03.008. Green open access

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Abstract

Orofacial granulomatosis (OFG) is an uncommon chronic inflammatory disorder of the orofacial region. It is characterized by subepithelial noncaseating granulomas and has a spectrum of possible clinical manifestations ranging from subtle oral mucosal swelling to permanent disfiguring fibrous swelling of the lips and face. Etiopathogenesis is unknown. A range of systemic granulomatous disorders, including Crohn disease and sarcoidosis, may cause orofacial manifestations that cannot be distinguished from those of OFG. Treatment of OFG has proven difficult and unsatisfactory, with no single therapeutic model showing consistent efficacy in reducing orofacial swelling and mucosal inflammation.

Type: Article
Title: Orofacial Granulomatosis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.det.2015.03.008
Publisher version: http://dx.doi.org/10.1016/j.det.2015.03.008
Language: English
Keywords: Crohn's disease, Granulomas, Granulomatous cheilitis, Melkersson-Rosenthal syndrome, Orofacial granulomatosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1470143
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