Mommersteeg, MT;
Yeh, ML;
Parnavelas, JG;
Andrews, WD;
(2015)
Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.
Cardiovascular Research
, 106
(1)
pp. 55-66.
10.1093/cvr/cvv040.
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Abstract
The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Slit-Robo signalling in the development of the murine membranous ventricular septum and cardiac valves.
| Type: | Article |
|---|---|
| Title: | Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/cvr/cvv040 |
| Publisher version: | http://dx.doi.org/10.1093/cvr/cvv040 |
| Language: | English |
| Additional information: | © The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Bicuspid aortic valves, Heart development, Membranous ventricular septum defect, Notch signalling pathway, Slit-Robo signalling pathway |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1470088 |
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