Yao, Z;
Petschnigg, J;
Ketteler, R;
Stagljar, I;
(2015)
Application guide for omics approaches to cell signaling.
Nature Chemical Biology
, 11
(6)
pp. 387-397.
10.1038/nchembio.1809.
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Abstract
Research in signal transduction aims to identify the functions of different signaling pathways in physiological and pathological states. Traditional techniques using biochemical, genetic or cell biological approaches have made important contributions to our understanding of cellular signaling. However, the single-gene approach does not take into account the full complexity of cell signaling. With the availability of omics techniques, great progress has been made in understanding signaling networks. Omics approaches can be classified into two categories: 'molecular profiling', including genomic, proteomic, post-translational modification and interactome profiling; and 'molecular perturbation', including genetic and functional perturbations.
| Type: | Article |
|---|---|
| Title: | Application guide for omics approaches to cell signaling |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nchembio.1809 |
| Publisher version: | http://dx.doi.org/10.1038/nchembio.1809 |
| Language: | English |
| Additional information: | © 2015 Nature America, Inc. All rights reserved. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1469859 |
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