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Application guide for omics approaches to cell signaling

Yao, Z; Petschnigg, J; Ketteler, R; Stagljar, I; (2015) Application guide for omics approaches to cell signaling. Nature Chemical Biology , 11 (6) pp. 387-397. 10.1038/nchembio.1809. Green open access

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Abstract

Research in signal transduction aims to identify the functions of different signaling pathways in physiological and pathological states. Traditional techniques using biochemical, genetic or cell biological approaches have made important contributions to our understanding of cellular signaling. However, the single-gene approach does not take into account the full complexity of cell signaling. With the availability of omics techniques, great progress has been made in understanding signaling networks. Omics approaches can be classified into two categories: 'molecular profiling', including genomic, proteomic, post-translational modification and interactome profiling; and 'molecular perturbation', including genetic and functional perturbations.

Type: Article
Title: Application guide for omics approaches to cell signaling
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nchembio.1809
Publisher version: http://dx.doi.org/10.1038/nchembio.1809
Language: English
Additional information: © 2015 Nature America, Inc. All rights reserved.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: https://discovery.ucl.ac.uk/id/eprint/1469859
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