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Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation.

Amelina, H; Subramaniam, S; Moiseeva, V; Armstrong, CA; Pearson, SR; Tomita, K; (2015) Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation. BMC Biol , 13 (1) , Article 37. 10.1186/s12915-015-0149-x. Green open access

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Abstract

Chromosomes reorganise in early meiotic prophase to form the so-called telomere bouquet. In fission yeast, telomeres localise to the nuclear periphery via interaction of the telomeric protein Rap1 with the membrane protein Bqt4. During meiotic prophase, the meiotic proteins Bqt1-2 bind Rap1 and tether to the spindle pole body to form the bouquet. Although it is known that this polarised chromosomal arrangement plays a crucial role in meiotic progression, the molecular mechanisms of telomere bouquet regulation are poorly understood.

Type: Article
Title: Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s12915-015-0149-x
Publisher version: http://dx.doi.org/10.1186/s12915-015-0149-x
Additional information: © 2015 Amelina et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/1469824
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