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Interaction of enamel matrix proteins with human periodontal ligament cells

Amin, HD; Olsen, I; Knowles, J; Dard, M; Donos, N; (2016) Interaction of enamel matrix proteins with human periodontal ligament cells. Clinical Oral Investigations , 20 (2) pp. 339-347. 10.1007/s00784-015-1510-8. Green open access

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Abstract

It has recently been shown that enamel matrix derivative (EMD) components (Fraction C, containing <6 kDa peptides (mainly a 5.3 kDa tyrosine-rich amelogenin peptide (TRAP)), and Fraction A, containing a mixture of >6 kDa peptides (including a leucine-rich amelogenin peptide (LRAP))) differentially regulate osteogenic differentiation of periodontal ligament (PDL) cells. The present study examined whether EMD and the EMD Fractions (i) bind and internalize into PDL cells and (ii) precipitate and form insoluble complexes on PDL cells.

Type: Article
Title: Interaction of enamel matrix proteins with human periodontal ligament cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00784-015-1510-8
Publisher version: http://dx.doi.org/10.1007/s00784-015-1510-8
Language: English
Additional information: © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: EMD, Periodontal ligament cells, Intracellular trafficking, EMD uptake, Receptor-mediated endocytosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1469821
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