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A Registration Approach to Endoscopic Laser Speckle Contrast Imaging for Intrauterine Visualisation of Placental Vessels

Sato Dos Santos, G; Maneas, E; Nikitichev, D; Barburas, A; David, AL; Deprest, J; Desjardins, A; ... Ourselin, S; + view all (2015) A Registration Approach to Endoscopic Laser Speckle Contrast Imaging for Intrauterine Visualisation of Placental Vessels. In: Frangi, AF and Hornegger, J and Navab, N and Wells, WM, (eds.) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015. (pp. pp. 455-462). Springer International Publishing Green open access

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Abstract

Intrauterine interventions such as twin-to-twin transfusion syndrome procedure require accurate mapping of the fetal placental vasculature to ensure complete photocoagulation of vascular anastomoses. However, surgeons are currently limited to fetoscopy and external ultrasound imaging, which are unable to accurately identify all vessels especially those that are narrow and at the periphery. Laser speckle contrast imaging (LSCI) is an optical method for imaging blood flow that is emerging as an intraoperative tool for neurosurgery. Here we explore the application of LSCI to minimally invasive fetal surgery, with an endoscopic LSCI system based on a 2.7-mm-diameter fetoscope. We establish using an optical phantom that it can image flow in 1-mm-diameter vessels as far as 4 mm below the surface. We demonstrate that a spatiotemporal algorithm produces the clearest images of vessels within 200 ms, and that speckle contrast images can be accurately registered using groupwise registration to correct for significant motion of target or probe. When tested on a perfused term ex vivo human placenta, our endoscopic LSCI system revealed small capillaries not evident in the fetoscopic images.

Type: Proceedings paper
Title: A Registration Approach to Endoscopic Laser Speckle Contrast Imaging for Intrauterine Visualisation of Placental Vessels
Event: MICCAI 2015, the 18th International Conference on Medical Image Computing and Computer Assisted Intervention
Location: Munich, Germany
Dates: 05 October 2015 - 09 October 2015
ISBN-13: 978-3-319-24552-2
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-319-24553-9_56
Publisher version: http://dx.doi.org/10.1007/978-3-319-24553-9_56
Language: English
Additional information: The original publication is available at www.springerlink.com
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1469322
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