Ma, D; Cardoso, MJ; Zuluaga, MA; Modat, M; Powell, N; Wiseman, F; Tybulewicz, V; ... Ourselin, S; + view all Ma, D; Cardoso, MJ; Zuluaga, MA; Modat, M; Powell, N; Wiseman, F; Tybulewicz, V; Fisher, E; Lythgoe, MF; Ourselin, S; - view fewer (2015) Grey matter sublayer thickness estimation in the mouse cerebellum. In: Navab, N and Hornegger, J and Wells, WM and Frangi, AF, (eds.) Proceedings of 18th International Conference in Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015. (pp. pp. 644-651). Springer International Publishing Switzerland: Munich, Germany.

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Abstract

The cerebellar grey matter morphology is an important feature to study neurodegenerative diseases such as Alzheimer’s disease or Down’s syndrome. Its volume or thickness is commonly used as a surrogate imaging biomarker for such diseases. Most studies about grey matter thickness estimation focused on the cortex, and little attention has been drawn on the morphology of the cerebellum. Using ex vivo highresolution MRI, it is now possible to visualise the different cell layers in the mouse cerebellum. In this work, we introduce a framework to extract the Purkinje layer within the grey matter, enabling the estimation of the thickness of the cerebellar grey matter, the granular layer and molecular layer from gadolinium-enhanced ex vivo mouse brain MRI. Application to mouse model of Down’s syndrome found reduced cortical and layer thicknesses in the transchromosomic group.

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