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Interventional photoacoustic imaging of the human placenta with ultrasonic tracking for minimally invasive fetal surgeries

Xia, W; Maneas, E; Nikitichev, D; Mosse, C; Sato dos Santos, G; Vercauteren, T; David, A; ... Desjardins, A; + view all (2015) Interventional photoacoustic imaging of the human placenta with ultrasonic tracking for minimally invasive fetal surgeries. Presented at: MICCAI 2015, the 18th International Conference on Medical Image Computing and Computer Assisted Intervention, Munich, Germany. Green open access

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Abstract

Image guidance plays a central role in minimally invasive fetal surgery, such as photocoagulation of inter-twin placental anastomosing vessels to treat twin-to-twin transfusion syndrome (TTTS). Fetoscopic guidance provides insufficient sensitivity for imaging the vasculature that lies beneath the fetal placental surface due to strong light scattering in biological tissues. Incomplete photocoagulation of anastamoses is associated with postoperative complications and higher perinatal mortality. In this study, we investigated the use of multi-spectral photoacoustic (PA) imaging for better visualization of the placental vasculature. Excitation light was delivered with an optical ber with dimensions that are compatible with the working channel of a fetoscope. Imaging was performed on an ex vivo normal term human placenta collected at Caesarean section birth. The photoacoustically-generated ultrasound signals were received by an external clinical linear array ultrasound imaging probe. A vein under illumination on the fetal placenta surface was visualized with PA, and good correspondence was obtained between the measured PA spectrum and the optical absorption spectrum of deoxy-genated blood. The delivery ber had an attached fiber optic ultrasound sensor positioned directly adjacent to it, so that its spatial position could be tracked by receiving transmissions from the ultrasound imaging probe. This study provides strong indications that PA imaging in combination with ultrasonic tracking could be useful for detecting the human placental vasculature during minimally invasive fetal surgery.

Type: Conference item (Presentation)
Title: Interventional photoacoustic imaging of the human placenta with ultrasonic tracking for minimally invasive fetal surgeries
Event: MICCAI 2015, the 18th International Conference on Medical Image Computing and Computer Assisted Intervention
Location: Munich, Germany
Dates: 05 October 2015 - 09 October 2015
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: To be published in the Lecture Notes in Computer Science (LNCS)series
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1469250
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