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Changing channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitability

Snowball, A; Schorge, S; (2015) Changing channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitability. FEBS Letters , 589 (14) pp. 1620-1634. 10.1016/j.febslet.2015.05.004. Green open access

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Abstract

Chronic pain and epilepsy together affect hundreds of millions of people worldwide. While traditional pharmacotherapy provides essential relief to the majority of patients, a large proportion remains resistant, and surgical intervention is only possible for a select few. As both disorders are characterised by neuronal hyperexcitability, manipulating the expression of the most direct modulators of excitability - ion channels - represents an attractive common treatment strategy. A number of viral gene therapy approaches have been explored to achieve this. These range from the up- or down-regulation of channels that control excitability endogenously, to the delivery of exogenous channels that permit manipulation of excitability via optical or chemical means. In this review we highlight the key experimental successes of each approach and discuss the challenges facing their clinical translation.

Type: Article
Title: Changing channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitability
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.febslet.2015.05.004
Publisher version: http://dx.doi.org/10.1016/j.febslet.2015.05.004
Additional information: Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Keywords: Chemogenetic, Chronic pain, Epilepsy, Gene therapy, Hyperexcitability, Ion channels, Optogenetic, Epilepsy, Genetic Therapy, Humans, Ion Channels, Neurons, Pain
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1469091
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