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Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study

Revier, CJ; Reininghaus, U; Dutta, R; Fearon, P; Murray, RM; Doody, GA; Croudace, T; ... Jones, PB; + view all (2015) Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study. Journal of Nervous and Mental Disease , 203 (5) pp. 379-386. 10.1097/NMD.0000000000000295. Green open access

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Abstract

It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

Type: Article
Title: Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/NMD.0000000000000295
Publisher version: http://dx.doi.org/10.1097/NMD.0000000000000295
Language: English
Additional information: Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Schizophrenia, psychosis, recovery, course and outcome, risk factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/1469025
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