Guggenheim, JA;
Allen, TJ;
Plumb, A;
Zhang, EZ;
Rodriguez-Justo, M;
Punwani, S;
Beard, PC;
(2015)
Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast.
Journal of Biomedical Optics
, 20
(5)
050504.
10.1117/1.JBO.20.5.050504.
![[thumbnail of Guggenheim JBO 2015.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) Preview |
Text
Guggenheim JBO 2015.pdf Available under License : See the attached licence file. Download (2MB) |
Abstract
Lymph nodes play a central role in metastatic cancer spread and are a key clinical assessment target. Abnormal node vascularization, morphology, and size may be indicative of disease but can be difficult to visualize with sufficient accuracy using existing clinical imaging modalities. To explore the potential utility of photoacoustic imaging for the assessment of lymph nodes, images of ex vivo samples were obtained at multiple wavelengths using a high-resolution three-dimensional photoacoustic scanner. These images showed that hemoglobin based contrast reveals nodal vasculature and lipid-based contrast reveals the exterior node size, shape, and boundary integrity. These two sources of complementary contrast may allow indirect observation of cancer, suggesting a future role for photoacoustic imaging as a tool for the clinical assessment of lymph nodes.
| Type: | Article |
|---|---|
| Title: | Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/1.JBO.20.5.050504 |
| Publisher version: | http://dx.doi.org/10.1117/1.JBO.20.5.050504 |
| Language: | English |
| Additional information: | Guggenheim, JA; Allen, TJ; Plumb, A; Zhang, EZ; Rodriguez-Justo, M; Punwani, S; Beard, PC; Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast. Journal of Biomedical Optics , 20 (5) 050504, (2015). Copyright 2015 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. DOI abstract link format: http://dx.doi.org/10.1117/1.JBO.20.5.050504 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1468985 |
Archive Staff Only
 |
View Item |
