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Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast

Guggenheim, JA; Allen, TJ; Plumb, A; Zhang, EZ; Rodriguez-Justo, M; Punwani, S; Beard, PC; (2015) Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast. Journal of Biomedical Optics , 20 (5) 050504. 10.1117/1.JBO.20.5.050504. Green open access

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Abstract

Lymph nodes play a central role in metastatic cancer spread and are a key clinical assessment target. Abnormal node vascularization, morphology, and size may be indicative of disease but can be difficult to visualize with sufficient accuracy using existing clinical imaging modalities. To explore the potential utility of photoacoustic imaging for the assessment of lymph nodes, images of ex vivo samples were obtained at multiple wavelengths using a high-resolution three-dimensional photoacoustic scanner. These images showed that hemoglobin based contrast reveals nodal vasculature and lipid-based contrast reveals the exterior node size, shape, and boundary integrity. These two sources of complementary contrast may allow indirect observation of cancer, suggesting a future role for photoacoustic imaging as a tool for the clinical assessment of lymph nodes.

Type: Article
Title: Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/1.JBO.20.5.050504
Publisher version: http://dx.doi.org/10.1117/1.JBO.20.5.050504
Language: English
Additional information: Guggenheim, JA; Allen, TJ; Plumb, A; Zhang, EZ; Rodriguez-Justo, M; Punwani, S; Beard, PC; Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast. Journal of Biomedical Optics , 20 (5) 050504, (2015). Copyright 2015 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. DOI abstract link format: http://dx.doi.org/10.1117/1.JBO.20.5.050504
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1468985
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