Evans, R; Zdebik, A; Ciurtin, C; Walsh, SB; (2015) Renal involvement in primary Sjögren's syndrome. Rheumatology , 54 (9) pp. 1541-1548. 10.1093/rheumatology/kev223.

Text Evans et al pSS Rheumatology Editorial proof.pdf Available under License : See the attached licence file. Download (321kB)

Abstract

SS is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function either as epithelial disease causing tubulointerstitial nephritis or as an immune complex-mediated glomerulopathy. These lesions may cause a variety of clinical features, both overt and occult. The epithelial disease is mediated by B and T cells, notably the Th17 subtype. We review the prevalence of renal SS, its presentation, likely pathogenesis and treatment.

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