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Renal involvement in primary Sjögren's syndrome

Evans, R; Zdebik, A; Ciurtin, C; Walsh, SB; (2015) Renal involvement in primary Sjögren's syndrome. Rheumatology , 54 (9) pp. 1541-1548. 10.1093/rheumatology/kev223. Green open access

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Abstract

SS is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function either as epithelial disease causing tubulointerstitial nephritis or as an immune complex-mediated glomerulopathy. These lesions may cause a variety of clinical features, both overt and occult. The epithelial disease is mediated by B and T cells, notably the Th17 subtype. We review the prevalence of renal SS, its presentation, likely pathogenesis and treatment.

Type: Article
Title: Renal involvement in primary Sjögren's syndrome
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/rheumatology/kev223
Publisher version: http://dx.doi.org/10.1093/rheumatology/kev223
Language: English
Additional information: © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com
Keywords: B cells, Fanconi syndrome, Sjögren’s syndrome, Th17 cells, autoantibodies, autoimmune epithelialitis, distal renal tubular acidosis, hypocomplementaemia, tubulointerstitial nephritis, vasculitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1468895
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