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Ageing does not result in a decline in cell synthetic activity in an injury prone tendon

Thorpe, CT; McDermott, BT; Goodship, AE; Clegg, PD; Birch, HL; (2015) Ageing does not result in a decline in cell synthetic activity in an injury prone tendon. Scandinavian Journal of Medicine & Science in Sports 10.1111/sms.12500. Green open access

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Abstract

Advancing age is a well-known risk factor for tendon disease. Energy-storing tendons [e.g., human Achilles, equine superficial digital flexor tendon (SDFT)] are particularly vulnerable and it is thought that injury occurs following an accumulation of micro-damage in the extracellular matrix (ECM). Several authors suggest that age-related micro-damage accumulates due to a failure of the aging cell population to maintain the ECM or an imbalance between anabolic and catabolic pathways. We hypothesized that ageing results in a decreased ability of tendon cells to synthesize matrix components and matrix-degrading enzymes, resulting in a reduced turnover of the ECM and a decreased ability to repair micro-damage. The SDFT was collected from horses aged 3-30 years with no signs of tendon injury. Cell synthetic and degradative ability was assessed at the mRNA and protein levels. Telomere length was measured as an additional marker of cell ageing. There was no decrease in cellularity or relative telomere length with increasing age, and no decline in mRNA or protein levels for matrix proteins or degradative enzymes. The results suggest that the mechanism for age-related tendon deterioration is not due to reduced cellularity or a loss of synthetic functionality and that alternative mechanisms should be considered.

Type: Article
Title: Ageing does not result in a decline in cell synthetic activity in an injury prone tendon
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/sms.12500
Publisher version: http://dx.doi.org/10.1111/sms.12500
Language: English
Additional information: This is the peer reviewed version of the following article: Thorpe, CT; McDermott, BT; Goodship, AE; Clegg, PD; Birch, HL; (2015) Ageing does not result in a decline in cell synthetic activity in an injury prone tendon. Scandinavian Journal of Medicine & Science in Sports, which has been published in final form at http://dx.doi.org/10.1111/sms.12500. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Tendon, ageing, degeneration, metabolism, telomere, tenocyte
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/1468762
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