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Complex motor task associated with non-linear BOLD responses in cerebro-cortical areas and cerebellum

Alahmadi, AA; Samson, RS; Gasston, D; Pardini, M; Friston, KJ; D'Angelo, E; Toosy, AT; (2016) Complex motor task associated with non-linear BOLD responses in cerebro-cortical areas and cerebellum. Brain Structure and Function , 221 (5) pp. 2443-2458. 10.1007/s00429-015-1048-1. Green open access

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Abstract

Previous studies have used fMRI to address the relationship between grip force (GF) applied to an object and BOLD response. However, whilst the majority of these studies showed a linear relationship between GF and neural activity in the contralateral M1 and ipsilateral cerebellum, animal studies have suggested the presence of non-linear components in the GF-neural activity relationship. Here, we present a methodology for assessing non-linearities in the BOLD response to different GF levels, within primary motor as well as sensory and cognitive areas and the cerebellum. To be sensitive to complex forms, we designed a feasible grip task with five GF targets using an event-related visually guided paradigm and studied a cohort of 13 healthy volunteers. Polynomial functions of increasing order were fitted to the data.

Type: Article
Title: Complex motor task associated with non-linear BOLD responses in cerebro-cortical areas and cerebellum
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00429-015-1048-1
Publisher version: http://dx.doi.org/10.1007/s00429-015-1048-1
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: fMRI; Force; MVC; Power grip; Visuomotor task
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1468229
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