Geng, J;
Gates, PB;
Kumar, A;
Guenther, S;
Garza-Garcia, A;
Kuenne, C;
Zhang, P;
... Brockes, JP; + view all
(2015)
Identification of the orphan gene Prod 1 in basal and other salamander families.
Evodevo
, 6
, Article 9. 10.1186/s13227-015-0006-6.
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Abstract
The urodele amphibians (salamanders) are the only adult tetrapods able to regenerate the limb. It is unclear if this is an ancestral property that is retained in salamanders but lost in other tetrapods or if it evolved in salamanders. The three-finger protein Prod 1 is implicated in the mechanism of newt limb regeneration, and no orthologs have been found in other vertebrates, thus providing evidence for the second viewpoint. It has also been suggested that this protein could play a role in salamander-specific aspects of limb development. There are ten families of extant salamanders, and Prod 1 has only been identified in two of them to date. It is important to determine if it is present in other families and, particularly, the basal group of two families which diverged approximately 200 MYA.
| Type: | Article |
|---|---|
| Title: | Identification of the orphan gene Prod 1 in basal and other salamander families. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s13227-015-0006-6 |
| Publisher version: | http://dx.doi.org/10.1186/s13227-015-0006-6 |
| Language: | English |
| Additional information: | © 2015 Geng et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Keywords: | Hynobiid, Limb regeneration, Phylogeny, Plethodontid, Three-finger protein |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1467010 |
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