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Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels

Dallérac, GM; Levasseur, G; Vatsavayai, SC; Milnerwood, AJ; Cummings, DM; Kraev, I; Huetz, C; ... Murphy, KP; + view all (2015) Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels. Neurodegenerative Diseases , 15 (2) 93 - 108. 10.1159/000375126. Green open access

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Abstract

Huntington's disease (HD) is a late-onset fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the gene coding for the protein huntingtin and is characterised by progressive motor, psychiatric and cognitive decline. We previously demonstrated that normal synaptic function in HD could be restored by application of dopamine receptor agonists, suggesting that changes in the release or bioavailability of dopamine may be a contributing factor to the disease process.

Type: Article
Title: Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000375126
Publisher version: http://dx.doi.org/10.1159/000375126
Language: English
Additional information: © 2015 S. Karger AG, Basel
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1466863
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