Hackett, RA;
Lazzarino, AI;
Carvalho, LA;
Hamer, M;
Steptoe, A;
(2015)
Hostility and Physiological Responses to Acute Stress in People With Type 2 Diabetes.
Psychosomatic Medicine
, 77
(4)
pp. 458-466.
10.1097/PSY.0000000000000172.
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Abstract
Objective: Hostility is associated with cardiovascular mortality and morbidity, and one of the mechanisms may involve heightened reactivity to mental stress. However, little research has been conducted in populations at high risk for cardiovascular disease. The aim of the present study was to assess the relationship between hostility and acute stress responsivity in individuals with Type 2 diabetes. Methods: A total of 140 individuals (median age [standard deviation] 63.71 [7.00] years) with Type 2 diabetes took part in laboratory-based experimental stress testing. Systolic blood pressure, diastolic blood pressure, heart rate, plasma interleukin-6 (IL-6), and salivary cortisol were assessed at baseline, during two stress tasks, and 45 and 75 minutes later. Cynical hostility was assessed using the Cook Medley Cynical Hostility Scale. Results: Participants with greater hostility scores had heightened increases in IL-6 induced by the acute stress tasks (B = 0.082, p = .002), independent of age, sex, body mass index, smoking, household income, time of testing, medication, and baseline IL-6. Hostility was inversely associated with cortisol output poststress (B = −0.017, p = .002), independent of covariates. No associations between hostility and blood pressure or heart rate responses were observed. Conclusions: Hostile individuals with Type 2 diabetes may be susceptible to stress-induced increases in inflammation. Further research is needed to understand if such changes increase the risk of cardiovascular disease in this population.
| Type: | Article |
|---|---|
| Title: | Hostility and Physiological Responses to Acute Stress in People With Type 2 Diabetes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/PSY.0000000000000172 |
| Publisher version: | http://dx.doi.org/10.1097/PSY.0000000000000172 |
| Language: | English |
| Additional information: | Copyright © 2015 by the American Psychosomatic Society This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
| Keywords: | Science & Technology, Social Sciences, Life Sciences & Biomedicine, Psychiatry, Psychology, Psychology, Multidisciplinary, Type 2 diabetes mellitus, hostility, interleukin-6, salivary cortisol, psychological stress, CORONARY-HEART-DISEASE, INSULIN-RESISTANCE, PSYCHOLOGICAL STRESS, PSYCHOSOCIAL FACTORS, CARDIOVASCULAR REACTIVITY, CAROTID ATHEROSCLEROSIS, INFLAMMATORY MARKERS, SALIVARY CORTISOL, ANGER EXPRESSION, RISK STATUS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1466856 |
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