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DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime?

van de Pavert, SH; Muhlert, N; Sethi, V; Wheeler-Kingshott, CA; Ridgway, GR; Geurts, JJ; Ron, M; ... Ciccarelli, O; + view all (2016) DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime? Journal of Neurology, Neurosurgery and Psychiatry , 87 (5) pp. 461-467. 10.1136/jnnp-2014-310142. Green open access

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Abstract

The extent and clinical relevance of grey matter (GM) pathology in multiple sclerosis (MS) are increasingly recognised. GM pathology may present as focal lesions, which can be visualised using double inversion recovery (DIR) MRI, or as diffuse pathology, which can manifest as atrophy. It is, however, unclear whether the diffuse atrophy centres on focal lesions. This study aimed to determine if GM lesions and GM atrophy colocalise, and to assess their independent relationship with motor and cognitive deficits in MS.

Type: Article
Title: DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2014-310142
Publisher version: http://dx.doi.org/10.1136/jnnp-2014-310142
Language: English
Additional information: © 2015 the authors. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
Keywords: IMAGE ANALYSIS, MRI, MULTIPLE SCLEROSIS, PATHOLOGY
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1466650
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