Musuamba, FT;
Teutonico, D;
Maas, HJ;
Facius, A;
Yang, S;
Danhof, M;
Della Pasqua, O;
(2015)
Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD).
Pharm Res
, 32
(2)
617 - 627.
10.1007/s11095-014-1490-4.
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Abstract
Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to contribute to this phenomenon, which can be clustered into drug-, disease- and design-related factors. Here we present a model-based approach to describe disease progression, treatment response and dropout in clinical trials with COPD patients.
| Type: | Article |
|---|---|
| Title: | Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11095-014-1490-4 |
| Publisher version: | http://dx.doi.org/10.1007/s11095-014-1490-4 |
| Language: | English |
| Additional information: | © The Author(s) 2014. This article is published with open access at Springerlink.com This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1466544 |
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