Tullet, JMA;
(2015)
DAF-16 target identification in C. elegans: past, present and future.
Biogerontology
, 16
(2)
221 - 234.
10.1007/s10522-014-9527-y.
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Abstract
In C. elegans , mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and functionally testing DAF-16 target genes has been a focal point of ageing research for the last 10 years. Here, I review the recent advances in identifying and understanding IIS/DAF-16 targets. These studies continue to reveal the intricate nature of the IIS/DAF-16 gene regulation network and are helping us to understand the mechanisms that control lifespan. Ageing and age related disease is an area of intense public interest, and the biochemical charac- terization of the genes involved will be critical for identifying drugs to improve the health of our ageing population.
| Type: | Article |
|---|---|
| Title: | DAF-16 target identification in C. elegans: past, present and future |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10522-014-9527-y |
| Publisher version: | http://dx.doi.org/10.1007/s10522-014-9527-y |
| Additional information: | Copyright © The Author(s) 2014. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution License which permits any use,distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Keywords: | Ageing, C. elegans, DAF-16, Insulin/IGF-1 like signalling, mRNA profiling, Proteomics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1466481 |
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