UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Impaired light detection of the circadian clock in a zebrafish melanoma model

Hamilton, N; Diaz-de-Cerio, N; Whitmore, D; (2015) Impaired light detection of the circadian clock in a zebrafish melanoma model. Cell Cycle , 14 (8) 1232 - 1241. 10.1080/15384101.2015.1014146. Green open access

[thumbnail of Hamilton et al. Impaired light detection.pdf]
Preview
Text
Hamilton et al. Impaired light detection.pdf

Download (472kB) | Preview

Abstract

The circadian clock controls the timing of the cell cycle in healthy tissues and clock disruption is known to increase tumourigenesis. Melanoma is one of the most rapidly increasing forms of cancer and the precise molecular circadian changes that occur in a melanoma tumor are unknown. Using a melanoma zebrafish model, we have explored the molecular changes that occur to the circadian clock within tumors. We have found disruptions in melanoma clock gene expression due to a major impairment to the light input pathway, with a parallel loss of light-dependent activation of DNA repair genes. Furthermore, the timing of mitosis in tumors is perturbed, as well as the regulation of certain key cell cycle regulators, such that cells divide arhythmically. The inability to co-ordinate DNA damage repair and cell division is likely to promote further tumourigenesis and accelerate melanoma development.

Type: Article
Title: Impaired light detection of the circadian clock in a zebrafish melanoma model
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/15384101.2015.1014146
Publisher version: http://dx.doi.org/10.1080/15384101.2015.1014146
Language: English
Additional information: © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC© Noémie Hamilton, Natalia Diaz-de-Cerio, and David Whitmore This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Keywords: cancer, cell cycle, circadian clock, light input, melanoma, zebrafish
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1466207
Downloads since deposit
115Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item