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Cortico-cortical connectivity within ferret auditory cortex

Bizley, JK; Bajo, VM; Nodal, FR; King, AJ; (2015) Cortico-cortical connectivity within ferret auditory cortex. Journal of Comparative Neurology , 523 (15) pp. 2187-2210. 10.1002/cne.23784. Green open access

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Abstract

Despite numerous studies of auditory cortical processing in the ferret (Mustela putorious), very little is known about the connections between the different regions of the auditory cortex that have been characterised cytoarchitectonically and physiologically. We examined the distribution of retrograde and anterograde labelling after injecting tracers into one or more regions of ferret auditory cortex. Injections of different tracers at frequency-matched locations in the core areas, the primary auditory cortex (A1) and anterior auditory field (AAF), of the same animal revealed the presence of reciprocal connections with overlapping projections to and from discrete regions within the posterior pseudosylvian and suprasylvian fields (PPF and PSF), suggesting that these connections are frequency specific. In contrast, projections from the primary areas to the anterior dorsal field (ADF) on the anterior ectosylvian gyrus were scattered and non-overlapping, consistent with the non-tonotopic organization of this field. The relative strength of the projections originating in each of the primary fields differed, with A1 predominantly targeting the posterior bank fields PPF and PSF, which in turn project to the ventral posterior field, whereas AAF projects more heavily to ADF, which then projects to the anteroventral field and the pseudosylvian sulcal cortex. These findings suggest that parallel anterior and posterior processing networks may exist, although the connections between different areas often overlap and interactions were present at all levels. This article is protected by copyright. All rights reserved.

Type: Article
Title: Cortico-cortical connectivity within ferret auditory cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/cne.23784
Publisher version: http://dx.doi.org/10.1002/cne.23784
Language: English
Additional information: © 2015 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1466139
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