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Preparation of polymeric nanoparticles by novel electrospray nanoprecipitation

Luo, CJ; Okubo, T; Nangrejo, M; Edirisinghe, M; (2015) Preparation of polymeric nanoparticles by novel electrospray nanoprecipitation. POLYMER INTERNATIONAL , 64 (2) pp. 183-187. 10.1002/pi.4822. Green open access

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Abstract

Polymeric nanoparticles have important applications in drug delivery, biotechnology, diagnostics and energy harvesting. We report a new technique named electrospray nanoprecipitation, which combines electrospray with agitated solvent displacement. The process enables one-step formation of polymeric nanoparticles <100 nm in size that are near-monodisperse with a diameter range significantly lower than could be obtained using either electrospray or agitated solvent displacement technique alone. Both reduction of polymer solution concentration and the addition of poly(vinyl alcohol) emulsifier in the water–non-solvent medium further reduce the average particle diameter. The technique provides an effective and straightforward method to further reduce the size range of near-monodisperse nanoparticles achievable in a single step, which can be readily adapted for reducing the achievable size range of core–shell structures using popular one-step encapsulation techniques such as coaxial electrospray. © 2014 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Type: Article
Title: Preparation of polymeric nanoparticles by novel electrospray nanoprecipitation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/pi.4822
Publisher version: http://dx.doi.org/10.1002/pi.4822
Language: English
Additional information: © 2014 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Electrospray, nanoprecipitation, nanoparticles, polymethylsilsesquioxane
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1466087
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