Christensen, KE;
Mikael, LG;
Leung, KY;
Lévesque, N;
Deng, L;
Wu, Q;
Malysheva, OV;
... Rozen, R; + view all
(2015)
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.
The American Journal of Clinical Nutrition
, 101
(3)
646 - 658.
10.3945/ajcn.114.086603.
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Abstract
Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions.
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