Begum, R;
Calaza, K;
Kam, JH;
Salt, TE;
Hogg, C;
Jeffery, G;
(2015)
Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster.
Biol Lett
, 11
(3)
10.1098/rsbl.2015.0073.
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Abstract
Ageing is an irreversible cellular decline partly driven by failing mitochondrial integrity. Mitochondria accumulate DNA mutations and reduce ATP production necessary for cellular metabolism. This is associated with inflammation. Near-infrared exposure increases retinal ATP in old mice via cytochrome c oxidase absorption and reduces inflammation. Here, we expose fruitflies daily to 670 nm radiation, revealing elevated ATP and reduced inflammation with age. Critically, there was a significant increase in average lifespan: 100-175% more flies survived into old age following 670 nm exposure and these had significantly improved mobility. This may be a simple route to extending lifespan and improving function in old age.
| Type: | Article |
|---|---|
| Title: | Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsbl.2015.0073 |
| Publisher version: | http://dx.doi.org/10.1098/rsbl.2015.0073 |
| Language: | English |
| Additional information: | © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| Keywords: | ATP, fly, inflammation, lifespan |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1465515 |
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