UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster.

Begum, R; Calaza, K; Kam, JH; Salt, TE; Hogg, C; Jeffery, G; (2015) Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster. Biol Lett , 11 (3) 10.1098/rsbl.2015.0073. Green open access

[thumbnail of 20150073.full.pdf] PDF
20150073.full.pdf

Download (392kB)

Abstract

Ageing is an irreversible cellular decline partly driven by failing mitochondrial integrity. Mitochondria accumulate DNA mutations and reduce ATP production necessary for cellular metabolism. This is associated with inflammation. Near-infrared exposure increases retinal ATP in old mice via cytochrome c oxidase absorption and reduces inflammation. Here, we expose fruitflies daily to 670 nm radiation, revealing elevated ATP and reduced inflammation with age. Critically, there was a significant increase in average lifespan: 100-175% more flies survived into old age following 670 nm exposure and these had significantly improved mobility. This may be a simple route to extending lifespan and improving function in old age.

Type: Article
Title: Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rsbl.2015.0073
Publisher version: http://dx.doi.org/10.1098/rsbl.2015.0073
Language: English
Additional information: © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Keywords: ATP, fly, inflammation, lifespan
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1465515
Downloads since deposit
112Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item