Kirkbride, JB;
(2014)
The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research.
Soc Psychiatry Psychiatr Epidemiol
, 49
(10)
1531 - 1534.
10.1007/s00127-014-0961-6.
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Abstract
In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in gene-environment interaction studies and the opportunities and challenges such approaches will bring to our understanding of the epidemiology of psychotic disorders, including schizophrenia.
| Type: | Article |
|---|---|
| Title: | The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research. |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00127-014-0961-6 |
| Publisher version: | http://dx.doi.org/10.1007/s00127-014-0961-6 |
| Language: | English |
| Additional information: | © The Author(s) 2014 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Keywords: | Environment, Gene-Environment Interaction, Humans, Models, Statistical, Molecular Biology, Schizophrenia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1465182 |
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