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Identification of environmental sounds and melodies in syndromes of anterior temporal lobe degeneration

Golden, HL; Downey, LE; Fletcher, PD; Mahoney, CJ; Schott, JM; Mummery, CJ; Crutch, SJ; (2015) Identification of environmental sounds and melodies in syndromes of anterior temporal lobe degeneration. Journal of the Neurological Sciences , 352 (1-2) pp. 94-98. 10.1016/j.jns.2015.03.007. Green open access

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Abstract

Recognition of nonverbal sounds in semantic dementia and other syndromes of anterior temporal lobe degeneration may determine clinical symptoms and help to define phenotypic profiles. However, nonverbal auditory semantic function has not been widely studied in these syndromes. Here we investigated semantic processing in two key nonverbal auditory domains - environmental sounds and melodies - in patients with semantic dementia (SD group; n=9) and in patients with anterior temporal lobe atrophy presenting with behavioural decline (TL group; n=7, including four cases with MAPT mutations) in relation to healthy older controls (n=20). We assessed auditory semantic performance in each domain using novel, uniform within-modality neuropsychological procedures that determined sound identification based on semantic classification of sound pairs. Both the SD and TL groups showed comparable overall impairments of environmental sound and melody identification; individual patients generally showed superior identification of environmental sounds than melodies, however relative sparing of melody over environmental sound identification also occurred in both groups. Our findings suggest that nonverbal auditory semantic impairment is a common feature of neurodegenerative syndromes with anterior temporal lobe atrophy. However, the profile of auditory domain involvement varies substantially between individuals.

Type: Article
Title: Identification of environmental sounds and melodies in syndromes of anterior temporal lobe degeneration
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jns.2015.03.007
Publisher version: http://dx.doi.org/10.1016/j.jns.2015.03.007
Additional information: © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/)
Keywords: Environmental sounds, Frontotemporal dementia, Frontotemporal lobar degeneration, Music, Semantic, Semantic dementia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1465140
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