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Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation.

Martinez de Pinillos Bayona, A; Moore, CM; Loizidou, M; MacRobert, AJ; Woodhams, JH; (2016) Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. International Journal of Cancer , 138 (5) pp. 1049-1057. 10.1002/ijc.29510. Green open access

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Abstract

Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes. There is a wide range of agents suitable for PCI-based delivery including toxins, oligonucleotides, genes and immunoconjugates which demonstrates the versatility of this technique. The basic mechanism of PCI involves triggering release of the agent from endolysosomes within the target cells using a photosensitiser which is selectively retained with the endolysosomal membranes. Excitation of the photosensitiser by visible light leads to disruption of the membranes via photooxidative damage thereby releasing the agent into the cytosol. This treatment enables the drugs to reach their intended subcellular target more efficiently and improves their efficacy. In this review we summarise the applications of this technique with the main emphasis placed on cancer chemotherapy.

Type: Article
Title: Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ijc.29510
Publisher version: http://dx.doi.org/10.1002/ijc.29510
Language: English
Additional information: © 2015 The Authors. Published by Wiley Periodicals, Inc. on behalf of UICC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: chemotherapy, drug delivery system, drug resistance, photochemical internalisation, photodynamic therapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/1464856
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