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Improving the Tuberculosis Drug Development Pipeline

Evangelopoulos, D; McHugh, TD; (2015) Improving the Tuberculosis Drug Development Pipeline. Chemical Biology & Drug Design , 86 (5) pp. 951-960. 10.1111/cbdd.12549. Green open access

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Abstract

Mycobacterium tuberculosis is considered one of the most successful pathogens and multidrug-resistant tuberculosis, a disease that urgently requires new chemical entities to be developed for treatment. There are currently several new molecules under clinical investigation in the tuberculosis (TB) drug development pipeline. However, the complex lifestyle of M. tuberculosis within the host presents a barrier to the development of new drugs. In this review, we highlight the reasons that make TB drug discovery and development challenging as well as providing solutions, future directions and alternative approaches to new therapeutics for TB.

Type: Article
Title: Improving the Tuberculosis Drug Development Pipeline
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/cbdd.12549
Publisher version: http://dx.doi.org/10.1111/cbdd.12549
Language: English
Additional information: This is the peer reviewed version of the following article: Evangelopoulos, D; McHugh, TD; (2015) Improving the Tuberculosis Drug Development Pipeline. Chemical Biology & Drug Design, 86 (5) pp. 951-960, which has been published in final form at: http://dx.doi.org/10.1111/cbdd.12549. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms).
Keywords: biological screening, drug development, gene expression, mechanism-based drug design, therapeutic target
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1464395
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