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Interactive neonatal gastrointestinal magnetic resonance imaging using fruit juice as an oral contrast media

Arthurs, OJ; Graves, MJ; Edwards, AD; Joubert, I; Set, PAK; Lomas, DJ; (2014) Interactive neonatal gastrointestinal magnetic resonance imaging using fruit juice as an oral contrast media. BMC Medical Imaging , 14 (1) 33 - ?. 10.1186/1471-2342-14-33. Green open access

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Abstract

Background: The objective was to evaluate the use of fruit juice with an interactive inversion recovery (IR) MR pulse sequence to visualise the gastrointestinal tract. Methods: We investigated the relaxation properties of 12 different natural fruit juices in vitro, to identify which could be used as oral contrast. We then describe our initial experience using an interactive MR pulse sequence to allow optimal visualisation after administering pineapple juice orally, and suppressing pre-existing bowel fluid contents, with variable TI in three adult and one child volunteer. Results: Pineapple juice (PJ) had both the shortest T1 (243 ms) and shortest T2 (48 ms) of the fruit juices tested. Optimal signal differentiation between pre-existing bowel contents and oral PJ administration was obtained with TIs of between 900 and 1100 ms. Conclusion: The use of an inversion recovery preparation allowed long T1 pre-existing bowel contents to be suppressed whilst the short T1 of fruit juice acts as a positive contrast medium. Pineapple juice could be used as oral contrast agent for neonatal gastrointestinal magnetic resonance imaging.

Type: Article
Title: Interactive neonatal gastrointestinal magnetic resonance imaging using fruit juice as an oral contrast media
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2342-14-33
Publisher version: http://dx.doi.org/10.1186/1471-2342-14-33
Additional information: © 2014 Arthurs et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Neonatal, MRI, Bowel, Fruit juice
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1464356
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