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Primary CNS Lymphoma

Phillips, EH; Fox, CP; Cwynarski, K; (2014) Primary CNS Lymphoma. Current Hematologic Malignancy Reports , 9 (3) 243 - 253. 10.1007/s11899-014-0217-2. Green open access

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Abstract

Primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system is an aggressive malignancy that exhibits unique biological features and characteristic clinical behaviour, with overall long-term survival rates of around 20–40 %. Clinical outcome has improved following the advent of chemoradiation protocols incorporating high-dose methotrexate in the mid-1980s, but disease relapse and adverse neurocognitive sequelae remain major clinical challenges. To address this, investigators have focused on improving drug therapy with novel cytotoxic combinations, monoclonal antibody therapy, and intensive chemotherapy consolidation approaches, in an attempt to improve disease control whilst reducing the requirement for whole-brain radiotherapy. Outcomes for patients that are older, immunocompromised, or have relapsed/refractory disease remain unsatisfactory and there is a paucity of clinical trial data to guide treatment of these groups. This review highlights recent advances in pathobiology, imaging, and clinical management of PCNSL and looks ahead to research priorities for this rare and challenging lymphoid malignancy.

Type: Article
Title: Primary CNS Lymphoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11899-014-0217-2
Publisher version: http://dx.doi.org/10.1007/s11899-014-0217-2
Language: English
Additional information: Available for re-use under a Creative Commons Attribution 4.0 International (CC BY) license. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the original author and source are properly attributed.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/1464291
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