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Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan

Garbowski, MW; Carpenter, JP; Smith, G; Roughton, M; Alam, MH; He, T; Pennell, DJ; (2014) Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan. Journal of Cardiovascular Magnetic Resonance , 16 (40) 10.1186/1532-429X-16-40. Green open access

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Abstract

There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complications of iron overload. Since the first demonstration of an inverse relationship between biopsy LIC and liver magnetic resonance (MR) using a proof-of-concept T2* sequence, MR technology has advanced dramatically with a shorter minimum echo-time, closer inter-echo spacing and constant repetition time. These important advances allow more accurate calculation of liver T2* especially in patients with high LIC.

Type: Article
Title: Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1532-429X-16-40
Publisher version: http://dx.doi.org/10.1186/1532-429X-16-40
Language: English
Additional information: © 2014 Garbowski et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Algorithms, Benzoates, Biological Markers, Biopsy, Blood Transfusion, Calibration, Hemosiderosis, Humans, Image Interpretation, Computer-Assisted, Iron, Iron Chelating Agents, Least-Squares Analysis, Linear Models, Liver, Magnetic Resonance Imaging, Observer Variation, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Triazoles
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/1464289
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