UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Dissecting the genetics of Inflammatory Bowel Disease

Elding, H; (2015) Dissecting the genetics of Inflammatory Bowel Disease. Doctoral thesis , UCL (University College London). Green open access

[img]
Preview
PDF
PhD_Thesis_H_Elding_postViva.pdf
Available under License : See the attached licence file.

Download (5MB)

Abstract

Inflammatory Bowel Disease (IBD) can be classified into two main subtypes: Crohn’s Disease (CD) and Ulcerative Colitis (UC). The aim of this study is to identify the genetic contribution to the susceptibility to IBD. In the first part of the study, I focused on Crohn’s Disease, the subtype that shows the greatest heritability. Using both pooled and sub-phenotype data, followed by replication, the results reveal substantial genetic heterogeneity and the total number of confirmed CD susceptibility loci was increased from 71 published by others to 200. This was achieved by analyzing the data using a multimarker approach and high-resolution genetic maps in Linkage Disequilibrium Units. In the second part of the study, I focused on Ulcerative Colitis. The results show that although UC has a lower reported heritability, many loci were also found for Ulcerative Colitis. Some of these overlap with those found for Crohn’s Disease.

Type: Thesis (Doctoral)
Title: Dissecting the genetics of Inflammatory Bowel Disease
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Part-published: Chapters II and III are published in the American Journal of Human Genetics: http://dx.doi.org/10.1016/j.ajhg.2011.11.006 http://dx.doi.org/10.1016/j.ajhg.2012.11.004
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/1464062
Downloads since deposit
83Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item