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Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.

Wild, EJ; Boggio, R; Langbehn, D; Robertson, N; Haider, S; Miller, JR; Zetterberg, H; ... Weiss, A; + view all (2015) Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. J Clin Invest 10.1172/JCI80743. Green open access

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Abstract

Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at very low levels in CSF and, to our knowledge, has never been measured previously.

Type: Article
Title: Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1172/JCI80743
Publisher version: http://dx.doi.org/10.1172/JCI80743
Additional information: Copyright © 2015 American Society for Clinical Investigation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > IoN Central Administration
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1463840
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