Wild, EJ;
              
      
            
                Boggio, R;
              
      
            
                Langbehn, D;
              
      
            
                Robertson, N;
              
      
            
                Haider, S;
              
      
            
                Miller, JR;
              
      
            
                Zetterberg, H;
              
      
            
            
          
      
            
            
          
      
            
            
          
      
            
            
          
      
            
            
            ... Weiss, A; + view all
            
          
      
        
        
        
    
  
(2015)
  Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.
J Clin Invest
      
    
    
    
         10.1172/JCI80743.
  
  
       
    
  
| ![[thumbnail of Wild.JCI80743-1.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) | PDF Wild.JCI80743-1.pdf Download (643kB) | 
Abstract
Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at very low levels in CSF and, to our knowledge, has never been measured previously.
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