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Taking the guesswork out of supplying multicompartment compliance aids: do pharmacists require further guidance on medication stability?

Gilmartin, JF; Raimi-Abraham, BT; Jani, Y; Smith, F; Orlu-Gul, M; (2015) Taking the guesswork out of supplying multicompartment compliance aids: do pharmacists require further guidance on medication stability? International Journal of Pharmacy Practice , 23 (5) pp. 367-369. 10.1111/ijpp.12183. Green open access

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Abstract

Objective The purpose of this article is to identify information that is currently available to pharmacists concerning the stability of medications repackaged into multicompartment compliance aids (MCAs). This article explores the potential risks associated with repackaging medications into MCAs for pharmacists who supply and patients who use them. Key findings There is a paucity of information currently available to pharmacists concerning the stability of medications repackaged into MCAs as it is not routinely provided by pharmaceutical manufacturers. However, some studies have identified the potential for adverse effects on safety, bioavailability and stability that may have a clinical impact. There are also professional and legal implications of removing medications from their original packaging for storage in MCAs. Conclusion There is a growing need for further information concerning the stability of medications repackaged into MCAs to guide pharmacists who are supplying these compliance aids to primary and secondary care. Pharmaceutical manufacturers and researchers should be advised to conduct stability testing in MCAs for orally administered medications. This information should be readily available, and pharmacists should be made aware of it via their pharmaceutical bodies. As a result, decisions regarding MCA preparation can be more informed, and pharmacist and patient risks associated with repackaging potentially unstable medications can be minimised.

Type: Article
Title: Taking the guesswork out of supplying multicompartment compliance aids: do pharmacists require further guidance on medication stability?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ijpp.12183
Publisher version: http://dx.doi.org/10.1111/ijpp.12183
Language: English
Additional information: This is the peer reviewed version of the following article: Gilmartin, J. F.-M., Raimi-Abraham, B. T., Jani, Y., Smith, F. and Orlu-Gul, M. (2015), Taking the guesswork out of supplying multicompartment compliance aids: do pharmacists require further guidance on medication stability?. International Journal of Pharmacy Practice, 23: 367–369, which has been published in final form at http://dx.doi.org/10.1111/ijpp.12183. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Community pharmacy, compliance aids, dispensing, product handling
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy
URI: https://discovery.ucl.ac.uk/id/eprint/1463514
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