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Animal models of fetal growth restriction: Considerations for translational medicine.

Swanson, AM; David, AL; (2015) Animal models of fetal growth restriction: Considerations for translational medicine. Placenta , 36 (6) pp. 623-630. 10.1016/j.placenta.2015.03.003. Green open access

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Abstract

Fetal growth restriction (FGR) is the failure of a fetus to reach its full genetic growth potential. It occurs in up to 8% of pregnancies, and after premature birth is the second leading cause of infant mortality and morbidity. There is no treatment currently available for FGR. Its primary cause, when not attributable to structural or genetic defects of the fetus, is 'placental insufficiency'. This broad definition covers the inability of the fetus to acquire sufficient nutrients and oxygen, and is influenced by a number of factors including altered maternal or fetal blood flow, reduced nutrient transport or changes in the placenta such as increased barrier thickness inhibiting nutrient transfer. For those researchers studying FGR and developing new therapies, choosing an animal model is a crucial consideration. It is vital to clearly frame the question being asked, as this will impact the factor influencing fetal nutrient delivery in the model, and will also affect the applicability of the results to the human condition. This review examines the range of in vivo models of FGR available for those engaged in translational research.

Type: Article
Title: Animal models of fetal growth restriction: Considerations for translational medicine.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.placenta.2015.03.003
Publisher version: http://dx.doi.org/10.1016/j.placenta.2015.03.003
Additional information: Copyright © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Animal models, Fetal growth restriction, Translational medicine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1463454
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