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Mobile genetic elements in Clostridium difficile and their role in genome function.

Mullany, P; Allan, E; Roberts, AP; (2015) Mobile genetic elements in Clostridium difficile and their role in genome function. Res Microbiol , 166 (4) pp. 361-367. 10.1016/j.resmic.2014.12.005. Green open access

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Abstract

Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This includes transfer of antibiotic resistance and other factors that allow the organism to survive challenging environments, modulation of toxin gene expression, transfer of the toxin genes themselves and the conversion of non-toxigenic strains to toxin producers. Mobile genetic elements have also been adapted by investigators to probe the biology of the organism and the various ways in which these have been used are reviewed.

Type: Article
Title: Mobile genetic elements in Clostridium difficile and their role in genome function.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.resmic.2014.12.005
Publisher version: http://dx.doi.org/10.1016/j.resmic.2014.12.005
Language: English
Additional information: © 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Bacteriophage, Conjugative transposon, Horizontal gene transfer, PaLoc, Tn5397, Tn916
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1463406
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