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The role of thymosin-β4 in kidney disease

Vasilopoulou, E; Winyard, PJ; Riley, PR; Long, DA; (2015) The role of thymosin-β4 in kidney disease. [Editorial comment]. Expert Opinion on Biological Therapy , 15 , Article Supplement 1. 10.1517/14712598.2015.1009891. Green open access

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Abstract

Therapies that modulate inflammation and fibrosis have the potential to reduce the morbidity and mortality associated with chronic kidney disease (CKD). A promising avenue may be manipulating thymosin-β4, a naturally occurring peptide, which is the major G-actin sequestering protein in mammalian cells and a regulator of inflammation and fibrosis. Thymosin-β4 is already being tested in clinical trials for heart disease and wound healing. This editorial outlines the evidence that thymosin-β4 may also have therapeutic benefit in CKD.

Type: Article
Title: The role of thymosin-β4 in kidney disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1517/14712598.2015.1009891
Publisher version: http://dx.doi.org/10.1517/14712598.2015.1009891
Language: English
Additional information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Biological Therapy on 22/06/15, available online: http://wwww.tandfonline.com/10.1517/14712598.2015.1009891
Keywords: Ac-SDKP, fibrosis, inflammation, kidney disease, thymosin-β4
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1462790
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