Yue, F;
Cheng, Y;
Breschi, A;
Vierstra, J;
Wu, W;
Ryba, T;
Sandstrom, R;
... Ren, B; + view all
(2014)
A comparative encyclopedia of DNA elements in the mouse genome.
Nature
, 515
(7527)
pp. 355-364.
10.1038/nature13992.
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Abstract
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.
| Type: | Article |
|---|---|
| Title: | A comparative encyclopedia of DNA elements in the mouse genome |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nature13992 |
| Publisher version: | http://dx.doi.org/10.1038/nature13992 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons AttributionNonCommercial-ShareAlike 3.0 Unported licence. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons. org/licenses/by-nc-sa/3.0 |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, TRANSCRIPTION FACTOR-BINDING, EMBRYONIC STEM-CELLS, PERVASIVE TRANSCRIPTION, CHROMATIN INTERACTIONS, EVOLUTIONARY DYNAMICS, TRANSPOSABLE ELEMENTS, ENCODE DATA, LANDSCAPE, GENE, EXPRESSION, Epigenomics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1462552 |
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