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APOBEC3 genes: retroviral restriction factors to cancer drivers

Henderson, S; Fenton, T; (2015) APOBEC3 genes: retroviral restriction factors to cancer drivers. Trends in Molecular Medicine , 21 (5) pp. 274-284. 10.1016/j.molmed.2015.02.007. Green open access

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Abstract

The APOBEC3 cytosine deaminases play key roles in innate immunity through their ability to mutagenize viral DNA and restrict viral replication. Recent advances in cancer genomics, together with biochemical characterization of the APOBEC3 enzymes, have now implicated at least two family members in somatic mutagenesis during tumor development. We review the evidence linking these enzymes to carcinogenesis and highlight key questions, including the potential mechanisms that misdirect APOBEC3 activity to the host genome, the links to viral infection, and the association between a common APOBEC3 polymorphism and cancer risk.

Type: Article
Title: APOBEC3 genes: retroviral restriction factors to cancer drivers
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.molmed.2015.02.007
Publisher version: http://dx.doi.org/10.1016/j.molmed.2015.02.007
Language: English
Additional information: © 2015. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0.
Keywords: APOBEC, cancer, mutagenesis, Animals, Carcinogenesis, Cytosine Deaminase, Humans, Immunity, Innate, Mutagenesis, Neoplasms, Retroviridae, Risk, Virus Replication
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/1462530
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