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Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis

Orgeta, V; Qazi, A; Spector, A; Orrell, M; (2015) Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis. British Journal of Psychiatry , 207 (4) pp. 293-298. 10.1192/bjp.bp.114.148130. Green open access

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Abstract

Background: Anxiety and depression are common in people with dementia and mild cognitive impairment (MCI) but there is uncertainty about the effectiveness of both pharmacological and psychological therapies. / Aims: To evaluate the evidence of effectiveness of psychological treatments in treating depression and anxiety in people with dementia and MCI. / Method: Systematic review and meta-analysis of randomized controlled trials of psychological treatment versus usual care in people with dementia and MCI. Primary outcomes were symptoms of anxiety and depression. Secondary outcomes were quality of life, ability to perform daily activities, neuropsychiatric symptoms, cognition, and carers' self-rated depressive symptoms. / Results: Six RCTs were included involving 439 participants with dementia, which used cognitive behavioural therapy, interpersonal therapy, counselling, or multimodal interventions including a specific psychological therapy. Beneficial effects were found for both depression and anxiety. Overall the quality of the evidence is moderate for depression and low for anxiety, due to methodological limitations of the studies identified and the limited number of trials. / Conclusions: Evidence from six randomised controlled trials suggests that psychological treatments are effective in reducing symptoms of depression and anxiety for people with dementia. There is a need for high quality multicentre trials including standardised, well defined interventions.

Type: Article
Title: Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.bp.114.148130
Publisher version: http://dx.doi.org/10.1192/bjp.bp.114.148130
Language: English
Additional information: Copyright © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/1462476
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