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Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies

(2014) Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. The Lancet Neurology , 13 (9) 893 - 903. 10.1016/S1474-4422(14)70171-1. Green open access

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Abstract

The epilepsies are a clinically heterogeneous group of neurological disorders. Despite strong evidence for heritability, genome-wide association studies have had little success in identifi cation of risk loci associated with epilepsy, probably because of relatively small sample sizes and insuffi cient power. We aimed to identify risk loci through meta-analyses of genome-wide association studies for all epilepsy and the two largest clinical subtypes (genetic generalised epilepsy and focal epilepsy).

Type: Article
Title: Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1474-4422(14)70171-1
Publisher version: http://dx.doi.org/10.1016/S1474-4422(14)70171-1
Additional information: Copyright © International League Against Epilepsy Consortium on Complex Epilepsies. Open Access article distributed under the terms of CC BY.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/1462326
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