Rohrer, JD; Nicholas, JM; Cash, DM; van Swieten, J; Dopper, E; Jiskoot, L; van Minkelen, R; ... Rossor, MN; + view all Rohrer, JD; Nicholas, JM; Cash, DM; van Swieten, J; Dopper, E; Jiskoot, L; van Minkelen, R; Rombouts, SA; Cardoso, MJ; Clegg, S; Espak, M; Mead, S; Thomas, DL; De Vita, E; Masellis, M; Black, SE; Freedman, M; Keren, R; MacIntosh, BJ; Rogaeva, E; Tang-Wai, D; Tartaglia, MC; Laforce, R; Tagliavini, F; Tiraboschi, P; Redaelli, V; Prioni, S; Grisoli, M; Borroni, B; Padovani, A; Galimberti, D; Scarpini, E; Arighi, A; Fumagalli, G; Rowe, JB; Coyle-Gilchrist, I; Graff, C; Fallström, M; Jelic, V; Ståhlbom, AK; Andersson, C; Thonberg, H; Lilius, L; Frisoni, GB; Pievani, M; Bocchetta, M; Benussi, L; Ghidoni, R; Finger, E; Sorbi, S; Nacmias, B; Lombardi, G; Polito, C; Warren, JD; Ourselin, S; Fox, NC; Rossor, MN; - view fewer (2015) Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis. Lancet Neurol , 14 (3) 253 - 262. 10.1016/S1474-4422(14)70324-2.

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Abstract

Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about a third of patients, the disease is caused by autosomal dominant genetic mutations usually in one of three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading frame 72 (C9orf72). Findings from studies of other genetic dementias have shown neuroimaging and cognitive changes before symptoms onset, and we aimed to identify whether such changes could be shown in frontotemporal dementia.

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