Coggins, AJ;
Tocher, DA;
Powner, MW;
(2015)
One-step protecting-group-free synthesis of azepinomycin in water.
Organic & Biomolecular Chemistry
, 13
(11)
3378 - 3381.
10.1039/c5ob00210a.
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Abstract
We report an efficient, atom economical general acid-base catalyzed one-step multi-gram synthesis of azepinomycin from commercially available compounds in water. We propose that the described pH-dependent Amadori rearrangement, which couples an amino-imidazole and simple sugar, is of importance as a potential step toward predisposed purine nucleotide synthesis at the origins of life.
| Type: | Article |
|---|---|
| Title: | One-step protecting-group-free synthesis of azepinomycin in water |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c5ob00210a |
| Publisher version: | http://dx.doi.org/10.1039/c5ob00210a |
| Language: | English |
| Additional information: | Copyright © Royal Society of Chemistry 2015 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1461252 |
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