Yamaji, M;
Mahmoud, M;
Evans, IM;
Zachary, IC;
(2015)
Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice.
PLoS One
, 10
(2)
, Article e0115563 . 10.1371/journal.pone.0115563.
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Abstract
Neuropilin 1 (NRP1) is a non-tyrosine kinase receptor for vascular endothelial growth factor (VEGF) and class 3 semaphorins, playing a role in angiogenesis and neuronal axon guidance, respectively. NRP1 is expressed in smooth muscle cells (SMC) but the functional role of NRP1 in SMC has not been elucidated. We therefore investigated the biological relevance of NRP1 in SMC in vivo by generating mice with SMC-specific Nrp1 deficiency.
| Type: | Article |
|---|---|
| Title: | Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0115563 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0115563 |
| Language: | English |
| Additional information: | © 2015 Yamaji et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1461210 |
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