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Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice.

Yamaji, M; Mahmoud, M; Evans, IM; Zachary, IC; (2015) Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice. PLoS One , 10 (2) , Article e0115563 . 10.1371/journal.pone.0115563. Green open access

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Abstract

Neuropilin 1 (NRP1) is a non-tyrosine kinase receptor for vascular endothelial growth factor (VEGF) and class 3 semaphorins, playing a role in angiogenesis and neuronal axon guidance, respectively. NRP1 is expressed in smooth muscle cells (SMC) but the functional role of NRP1 in SMC has not been elucidated. We therefore investigated the biological relevance of NRP1 in SMC in vivo by generating mice with SMC-specific Nrp1 deficiency.

Type: Article
Title: Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0115563
Publisher version: http://dx.doi.org/10.1371/journal.pone.0115563
Language: English
Additional information: © 2015 Yamaji et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1461210
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