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Developmental mismatch: consequences for later cardiorespiratory health

Pike, KC; Hanson, MA; Godfrey, KM; (2008) Developmental mismatch: consequences for later cardiorespiratory health. BJOG: An International Journal of Obstetrics & Gynaecology , 115 (2) pp. 149-157. 10.1111/j.1471-0528.2007.01603.x. Green open access

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Abstract

Clinical and epidemiological studies have established that people who were small at birth and had poor infant growth have an increased risk of adult cardiovascular and respiratory disease, particularly if their restricted early growth is followed by accelerated childhood weight gain. This relationship extends across the normal range of infant size in a graded manner. The 'mismatch hypothesis' proposes that ill health in later life originates through developmental plastic responses made by the fetus and infant; these responses increase the risk of adult disease if the environment in childhood and adult life differs from that predicted during early development.

Type: Article
Title: Developmental mismatch: consequences for later cardiorespiratory health
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/j.1471-0528.2007.01603.x
Publisher version: http://doi.org/10.1111/j.1471-0528.2007.01603.x
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cardiovascular disease; epigenetic; fetal growth; maternal nutrition; respiratory disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1461065
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