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Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence

Pike, KC; Davis, SA; Collins, SA; Lucas, JS; Inskip, HM; Wilson, SJ; Thomas, ER; ... Holloway, JW; + view all (2014) Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. Scientific Reports , 4 , Article 4705. 10.1038/srep04705. Green open access

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Abstract

Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperreactivity is investigated in an animal model and evidence for comparable associations is sought in humans. Pregnant Wistar rats were fed either control or protein-restricted diets throughout pregnancy. Bronchoconstrictor responses were recorded from offspring bronchial segments. Morphometric analysis of paraffin-embedded lung sections was conducted. In a human mother-child cohort ultrasound measurements of fetal growth were related to bronchial hyperreactivity, measured at age six years using methacholine. Protein-restricted rats' offspring demonstrated greater bronchoconstriction than controls. Airway structure was not altered. Children with lesser abdominal circumference growth during 11-19 weeks' gestation had greater bronchial hyperreactivity than those with more rapid abdominal growth. Imbalanced maternal nutrition during pregnancy results in offspring bronchial hyperreactivity. Prenatal environmental influences might play a comparable role in humans.

Type: Article
Title: Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/srep04705
Publisher version: http://dx.doi.org/10.1038/srep04705
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/.
Keywords: Animals, Bronchi, Bronchoconstrictor Agents, Diet, Protein-Restricted, Embryo, Mammalian, Embryonic Development, Female, Humans, Lung, Models, Animal, Pregnancy, Pregnancy, Animal, Prenatal Exposure Delayed Effects, Rats
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1461064
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