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Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years

Pike, KC; Calder, PC; Inskip, HM; Robinson, SM; Roberts, GC; Cooper, C; Godfrey, KM; (2012) Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years. Clinical and Developmental Immunology , 2012 , Article 474613. 10.1155/2012/474613. Green open access

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Abstract

Variation in exposure to polyunsaturated fatty acids (PUFAs) might influence the development of atopy, asthma, and wheeze. This study aimed to determine whether differences in PUFA concentrations in maternal plasma phosphatidylcholine are associated with the risk of childhood wheeze or atopy. For 865 term-born children, we measured phosphatidylcholine fatty acid composition in maternal plasma collected at 34 weeks' gestation. Wheezing was classified using questionnaires at 6, 12, 24, and 36 months and 6 years. At age of 6 years, the children underwent skin prick testing, fractional exhaled nitric oxide (FENO) measurement, and spirometry. Maternal n-6 fatty acids and the ratio of n-3 to n-6 fatty acids were not associated with childhood wheeze. However, higher maternal eicosapentaenoic acid, docosahexaenoic acid, and total n-3 fatty acids were associated with reduced risk of non-atopic persistent/late wheeze (RR 0.57, 0.67 and 0.69, resp. P = 0.01, 0.015, and 0.021, resp.). Maternal arachidonic acid was positively associated with FENO (P = 0.024). A higher ratio of linoleic acid to its unsaturated metabolic products was associated with reduced risk of skin sensitisation (RR 0.82, P = 0.013). These associations provide some support for the hypothesis that variation in exposure to n-6 and n-3 fatty acids during pregnancy influences the risk of childhood wheeze and atopy.

Type: Article
Title: Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years
Location: Egypt
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2012/474613
Publisher version: http://dx.doi.org/10.1155/2012/474613
Language: English
Additional information: Copyright © 2012 Katharine C. Pike et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Asthma, Child, Child, Preschool, Dermatitis, Atopic, Fatty Acids, Omega-3, Fatty Acids, Omega-6, Female, Follow-Up Studies, Humans, Hypersensitivity, Immediate, Infant, Maternal Exposure, Phosphatidylcholines, Pregnancy, Prenatal Exposure Delayed Effects, Respiratory Function Tests, Respiratory Sounds, Risk Factors, Skin Tests, Spirometry, Surveys and Questionnaires, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1461062
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